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The post says providers should assess baseline UTI history, diabetes status and urological anatomy before starting therapy, and that some patients benefit from periodic urinalysis to catch asymptomatic bacteriuria
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8,48,49 In addition, the fact that circulating GLP-1 is rapidly degraded by the enzyme dipeptidyl peptidase-4 (DPP-4) argued against activation of GLP1R in the CNS by peripheral GLP-1